The Anticancer Drug Methotrexate Inhibits Nucleotide Synthesis

Multiple Choice

The anticancer drug methotrexate inhibits nucleotide synthesis.Which of the following explains why it also inhibits the synthesis of histidine and methionine?

A) The synthetic pathways for these amino acids require tetrahydrofolate for group transfer reactions.
B) These amino acids are derivatives of the nucleotides UTP and GTP.
C) Without the synthesis of nucleotides,there is not sufficient energy for the synthesis of the amino acids.
D) <ethotrexate inhibits also inhibits the precursors for these amino acids.
E) all of the above