A Man and His Sister Are Both Affected with a Mitochondrial

Multiple Choice

A man and his sister are both affected with a mitochondrial disorder. Because the sister has two children who also have the disorder, the man is concerned about thepossibility of also having children with the disorder. What is the estimated risk for each pregnancy of this man producing a child with the same mitochondrial disorder that he has if his wife does not have a mitochondrial disorder?

A) 100%
B) 50%
C) 25%
D) 0%