What Factor Would Limit the Ability of the H₂CO₃/HCO₃^- Buffer

Multiple Choice

What factor would limit the ability of the H₂CO₃/HCO₃^- buffer system to perform efficiently?

A) Temperature rise of more than 3° C
B) Inadequate amount of 2,3-DPG in the blood
C) Increased production of nonvolatile acids
D) Lungs failing to excrete adequate levels of CO₂