Which of the Following Is/are True About the Relationship Between

Multiple Choice

Which of the following is/are true about the relationship between chloride (Cl^-) and bicarbonate HCO₃^- in acid-base balance?
1) For each Cl^- ion excreted into the urine, the blood gains an HCO₃^- ion.
2) Blood Cl^- and HCO₃^- ion levels are reciprocally related.
3) People with chronically high CO₂ tend to have low blood Cl^- levels.
4) Activation of the NH₃ buffer system enhances Cl^- gain and HCO₃ loss.

A) 2 and 3 only
B) 1, 2, and 3 only
C) 2 only
D) 2, 3, and 4 only