Which Gives Rise to a Favorable Enthalpic ( S)driving

Multiple Choice

Which gives rise to a favorable enthalpic ( S) driving force for protein folding?

A) The lining up of hydrogen bonds as the protein folds.
B) The limiting of possible conformations as the protein folds.
C) The decrease in ordered water molecules as hydrophobic amino acids pack together.
D) The stabilization caused by favorable electrostatic interactions of amino acid side chains.