How Would an Increased Level of Acetyl-CoA Be Expected to Affect

Multiple Choice

How would an increased level of acetyl-CoA be expected to affect the pyruvate dehydrogenase reaction?

A) The pyruvate dehydrogenase kinase enzyme activity would increase, resulting in an inhibition of pyruvate dehydrogenase activity.
B) The last step of the pyruvate dehydrogenase reaction would be blocked, resulting in a decrease in activity.
C) The E1 subunit would be phosphorylated by pyruvate dehydrogenase kinase, and the catalytic activity of pyruvate dehydrogenase would decrease.
D) The pyruvate dehydrogenase phosphatase-1 enzyme would increase, resulting in pyruvate dehydrogenase activation at an accelerated rate.