Interphase FISH Has Been Performed on a Patient Sample

Multiple Choice

Interphase FISH has been performed on a patient sample. With a chromosome 8 centromeric (CEP 8) probe, two signals are observed in each spread examined. A probe for the immunoglobulin heavy chain region on chromosome 14 gives two distinct signals per nucleus, and a probe for the myc gene on chromosome 8 gives two distinct signals per nucleus. Which of following interpretations is correct?

A) The patient is normal.
B) The patient has a t(14;8) translocation.
C) The patient has a chromosome 8 deletion.
D) The patient has a chromosome 8 insertion.