Question 1

Pharmacokinetic changes with aging is reflective of:

Accepted Answer

A)  What the drug does to the body 
B)  What the body does to the drug 
C)  The effect at the site of action and the time and intensity of the drug 
D)  The side effects commonly associated with the drug B

Question 2

All of the following statements are true about drug distribution in the elderly except:

Accepted Answer

A)  Drugs distributed in water have lower concentration 
B)  Drugs distributed in fat have less intense,more prolonged effect 
C)  Drugs highly protein bound have greater potential to cause an adverse drug reaction 
D)  The fastest way to deliver a drug to the action site is by inhalation A

Question 3

Biochemical individuality is best described as:

Accepted Answer

A)  Each individual's variation is often much greater than that of a larger group 
B)  The unique biochemical profile of a selected population 
C)  The truly "normal" individual-falling within average range 
D)  Each individual's variation is often much smaller than that of a larger group D

Question 4

All of the following statements are true about laboratory values in older adults except:

Accepted Answer

A)  Reference ranges are preferable 
B)  Abnormal findings are often due to physiological aging 
C)  Normal ranges may not be applicable for older adults 
D)  Reference values are not necessarily acceptable values

Question 5

Functional abilities are best assessed by:

Accepted Answer

A)  Self-report of function 
B)  Observed assessment of function 
C)  A comprehensive head-to-toe examination 
D)  Family report of function

Question 6

Polypharmacy is best described as taking:

Accepted Answer

A)  More than nine medications per day 
B)  More than five medications per day 
C)  Even a single medication if there is not a clear indication for its use 
D)  When a drug is given to treat the side effect of another drug

Question 7

The major impact of the physiological changes that occur with aging is:

Accepted Answer

A)  Reduced physiological reserve 
B)  Reduced homeostatic mechanisms 
C)  Impaired immunological response 
D)  All of the above

Question 8

Atypical presentation of disease in the elderly is reflected by all the following except:

Accepted Answer

A)  Infection without fever 
B)  Depression without dysphoric mood 
C)  Myocardial infarction with chest pain and diaphoresis 
D)  Cardiac manifestations of thyroid disease

Question 9

All the following statements are false about drug absorption except:

Accepted Answer

A)  Antacids increase the bioavailability of digitalis 
B)  Gastric acidity decreases with age 
C)  Anticholinergics increase colonic motility 
D)  Underlying chronic disease has little impact on drug absorption

Question 10

A statement not shown to be true about pharmacodynamics changes with aging is:

Accepted Answer

A)  Decreased sensitivity to oral anticoagulants 
B)  Enhanced sensitivity to central nervous system drugs 
C)  Drug responsiveness can be influenced by patient activity level 
D)  There is a decreased sensitivity to beta blockers

Question 11

Men have faster and more efficient biotransformation of drugs and this is thought to be due to:

Accepted Answer

A)  Less obesity rates than women 
B)  Prostate enlargement 
C)  Testosterone 
D)  Less estrogen than women

Question 12

The cytochrome p system involves enzymes that are generally:

Accepted Answer

A)  Inhibited by drugs 
B)  Induced by drugs 
C)  Inhibited or induced by drugs 
D)  Associated with decreased liver perfusion

Question 13

The strongest evidence regarding normal physiological aging is available through:

Accepted Answer

A)  Randomized controlled clinical trials 
B)  Cross-sectional studies 
C)  Longitudinal studies 
D)  Case control studies

Exam 1: Changes With Aging