Refer to the Figure Showing the Effects of Four Allosteric

Multiple Choice

Refer to the figure showing the effects of four allosteric modifiers of the enzyme phosphofructokinase (PFK) .Green arrows indicate allosteric activators, and red lines indicate allosteric inhibitors. Which statement correctly explains how one of these regulatory molecules functions to regulate flow of matter through the glycolytic pathway?

A) When cellular ATP concentration is high as the result of low metabolic demand, ATP binds to and inhibits PFK to decrease flux through the pathway.
B) When cellular citrate concentration is high as the result of low metabolic demand, citrate binds to and activates PFK to increase flux through the pathway.
C) When cellular AMP concentration is high as the result of high metabolic demand, AMP binds to and inhibits PFK to decrease flux through the pathway.
D) When cellular citrate concentration is low as the result of low metabolic demand, citrate binds to and inhibits PFK to decrease flux through the pathway.
E) When cellular ADP concentration is low as the result of high metabolic demand, ADP binds to and activates PFK to increase flux through the pathway.