Refer to the Table

Multiple Choice

Refer to the table. Alkaptonuria is an inborn error of metabolism, caused by defects in an enzyme in the pathway that breaks down tyrosine (see Section 14.1) .Humans who are homozygous for one of these mutations make nonfunctional enzyme and accumulate the enzyme's substrate, homogentisic acid, which causes their disease symptoms.In 1996, researchers in Spain cloned and sequenced the gene for the enzyme and characterized several mutant alleles.The table shows the wild-type coding strand sequence for part of the gene and the corresponding region from one of the mutant alleles.What type of mutation is this?

A) Silent
B) Nonsense
C) Frame-shift
D) Missense
E) Reversion