Which Event Would Lead to a Reduction in Gene Expression

Multiple Choice

Which event would lead to a reduction in gene expression?

A) Mutation of the DNA-binding domain of an activator, changing its shape
B) Mutation of the binding site of a co-repressor molecule within a repressor protein
C) Removal of all methylation marks from a region of DNA
D) Remodeling of the chromatin environment, resulting in removal of histone octamers from a gene's promoter region
E) Mutation of a TATA box to create a tighter binding of RNA polymerase to the DNA