A Hypothetical Drug Has a Side Effect of Increasing Blood

Multiple Choice

A hypothetical drug has a side effect of increasing blood pressure.Individuals who are homozygous for G at SNP 1 break down this drug faster than average.Individuals who are homozygous for A at SNP 2 break down this drug slower than average.The effects of these two SNPs roughly cancel each other out, such that homozygotes at both SNPs generally have average rates of breakdown of the enzyme.Which combination of genotypes is most likely to put an individual at risk for having the side effect? (Note: The genotype of SNP 1 is listed first, followed by that of SNP 2.)

A) GG, AA
B) GG, AG
C) CC, AA
D) GC, AG
E) GC, GG