Which Statement About Nonsynonymous Substitutions Is True

Multiple Choice

Which statement about nonsynonymous substitutions is true?

A) They always affect the protein's shape and charge.
B) They occasionally confer a selective advantage on the organism.
C) The frequency of their occurrence is roughly the same among different genes.
D) They are unlikely to be influenced by natural selection.
E) In most genes, they occur more frequently than synonymous substitutions do.