The Sickness Whooping Cough Is Caused by Infection with the Bacterium

Multiple Choice

The sickness whooping cough is caused by infection with the bacterium Bordetella pertussis, which produces pertussis toxin.This toxin inhibits the activity of a protein that regulates adenylyl cyclase.One symptom of this inhibition is the development of a severe cough that can be so strong that it breaks ribs.Vaccines for B.pertussis are effective, but the bacterium can develop sequence differences that allow it to escape detection by the immune system.To develop an updated vaccine that confers immunity to a new strain of B.pertussis, researchers would

A) use bioprospecting.
B) compare paralogs.
C) study cross-species transmission.
D) compare the genomes of old and new strains.
E) evaluate concerted evolution.