Which of the Following Is the Earliest Event in Puberty

Multiple Choice

Which of the following is the earliest event in puberty?

A) The hypothalamus releases more GnRH.
B) The level of circulating androgens rises in males.
C) The menstrual cycle is initiated in females.
D) The gonads differentiate into testes or ovaries.
E) The hypothalamic GnRH-producing cells become more sensitive to negative feedback from sex steroids and gonadotropins.