Isosorbide Dinitrate Is Prescribed for a Patient with Chronic Stable

Multiple Choice

Isosorbide dinitrate is prescribed for a patient with chronic stable angina. This drug is administered twice daily, but the schedule is 7 a.m. and 2 p.m. because:

A) It is a long-acting drug with potential for toxicity.
B) Nitrate tolerance can develop.
C) Orthostatic hypotension is a common adverse effect.
D) It must be taken with milk or food.