Canine Phosphofructokinase (PFK) Deficiency Afflicts Springer Spaniels, Affecting an Estimated

Multiple Choice

Canine phosphofructokinase (PFK) deficiency afflicts Springer spaniels, affecting an estimated 10 percent of the breed. Given its critical role in glycolysis, one implication of the genetic defect resulting in PFK deficiency in dogs is ________.

A) early embryonic mortality
B) elevated blood-glucose levels in the dog's blood
C) an intolerance for exercise
D) a reduced life span