Which of the Following Mutations Would You Expect to Cause

Multiple Choice

Which of the following mutations would you expect to cause the most drastic alteration in the functional performance of a polypeptide chain? (Assuming the replacement is not at the active site)

A) Replacement of glutamate with lysine.
B) Replacement of valine with alanine.
C) Replacement of aspartic acid with glutamic acid.
D) Replacement of lysine with arginine.