In the Normal Red Blood Cell, 2,3-BPG Binds to Alpha-Amino

Multiple Choice

In the normal red blood cell, 2,3-BPG binds to alpha-amino groups of hemoglobin. What would happen to the O2-saturation curve of Hb in the presence of normal amounts of 2,3-BPG if a drug were administered that prevents the binding of 2,3-BPG to Hb?

A) the curve would be shifted to the left from that of normal red cells
B) the concentration of O₂ necessary to saturate Hb would be lower than that normally required
C) the amount of O₂ delivered to the tissue for a given partial pressure of O₂ (e.g., 40 mm Hg) would be lower than normal
D) all of the above
E) none of the above