Which of the Following Statements About the Interaction of Heme

Multiple Choice

Which of the following statements about the interaction of heme units of hemoproteins with oxygen is correct?

A) Binding of 2,3-bisphosphoglycerate (BPG) to hemoglobin leads to increased binding of oxygen.
B) Binding of oxygen to one myoglobin increases the strength of binding of oxygen to other myoglobins.
C) In blood of peripheral tissues, the loss of an oxygen by a heme unit is balanced stoichiometrically by the loss of one hydrogen.
D) The binding of oxygen by separated beta-chains of hemoglobin is described by a sigmoid curve.
E) As oxygen binds to hemoglobin, the pKa's of certain amino acid sidechains decrease.