Which of the Following Is a Likely Mechanism for Long-Term

Multiple Choice

Which of the following is a likely mechanism for long-term potentiation?

A) When glutamate binds to postsynaptic AMPA receptors, it activates intracellular changes.
B) When glutamate binds to NMDA receptors, it allows magnesium ions to enter the cell, which initiate intracellular changes.
C) When sufficient glutamate is released by the presynaptic neuron, it dislodges Mg²⁺ from the AMPA receptors and allows Ca²⁺ to leave the cell.
D) When sufficient glutamate is released, both AMPA and NMDA receptors are activated, and NMDA receptors allow Ca²⁺ as well as Na⁺ to enter the cell, thus initiating intracellular changes.
E) When both glutamate and ACh are released together, they create a long-lasting depolarization of the postsynaptic cell.