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Based on Your Knowledge of Electrophilic Aromatic Substitution,and Assuming the Pyrrole

Question 105

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Based on your knowledge of electrophilic aromatic substitution,and assuming the pyrrole ring of indole (shown)is activated toward electrophilic aromatic substituted more so than the benzenoid ring,predict the preferential position of attack of an electrophile,i.e.,does the electrophile E+ attack carbon 2,or 3? Explain your answer. Based on your knowledge of electrophilic aromatic substitution,and assuming the pyrrole ring of indole (shown)is activated toward electrophilic aromatic substituted more so than the benzenoid ring,predict the preferential position of attack of an electrophile,i.e.,does the electrophile E<sup>+</sup> attack carbon 2,or 3? Explain your answer. Which substitution product forms preferentially and why? Which substitution product forms preferentially and why?

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3-substitution is preferred,since this l...

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