Thymine Nucleotides Are Not Synthesized Directly by Cells but Indirectly

Multiple Choice

Thymine nucleotides are not synthesized directly by cells but indirectly from other pyrimidine deoxyribonucleotides. All of the following statements regarding thymine nucleotide synthesis are true EXCEPT:

A) dUMP is the immediate precursor for dTMP.
B) The action of dUTPase allows dUTP to serve as a substrate in DNA synthesis.
C) Thymidylate synthase catalyzes the formation of dTMP from dUMP.
D) The methyl donor in the reaction of dTMP is N⁵, N¹⁰-methylene-THF.
E) THF is used as a cofactor.