Which of the Following Does NOT Apply to the Reaction

Multiple Choice

Which of the following does NOT apply to the reaction catalyzed by the pyruvate dehydrogenase complex?

A) The process is highly exergonic and essentially irreversible in vivo.
B) Each intermediate in the five step reaction is able to diffuse to the next active site in a sequential manner.
C) It takes place in the mitochondrion.
D) It is an oxidative decarboxylation.
E) The product is acetyl CoenzymeA.