How Does PTEN Affect the Balance Between Proapoptotic and Antiapoptotic

Multiple Choice

How does PTEN affect the balance between proapoptotic and antiapoptotic signals?

A) PTEN removes the phosphate group from the 3-position of PIP₃ converting it to PI(4,5) P₂,which cannot activate PKB (AKT) and thus throws the balance in an antiapoptotic direction.
B) PTEN removes the phosphate group from the 3-position of PIP₃ converting it to PI(4,5) P₂,which cannot activate PKB (AKT) and thus throws the balance in a proapoptotic direction.
C) PTEN cuts a phosphate group off of PKB,which throws the balance in a proapoptotic direction.
D) PTEN cuts a phosphate group off of PKB,which throws the balance in an antiapoptotic direction.
E) PTEN adds a phosphate group to PKB,which throws the balance in a proapoptotic direction.