If Patients with Advanced CML Are Initially Treated with Gleevec,they

Multiple Choice

If patients with advanced CML are initially treated with Gleevec,they generally develop resistance to the drug within a few months.What seems to cause the resistance?

A) mutations in the BCR portion of the fusion gene
B) mutations in the ABL portion of the fusion gene
C) ABL gene deletion
D) ABL gene amplification
E) BCR gene amplification