Which of the Following Description of T Cell Responses to Tumor

Multiple Choice

Which of the following description of T cell responses to tumor antigens is correct?

A) Most anti-tumor T cell responses are specific for mutant peptides bound to class II MHC molecules.
B) Cancer patients whose tumors have relatively high mutation burdens are less likely to mount effective -anti-tumor T cell responses.
C) The majority of anti-tumor T cell responses in cancer patients are specific for mutations,which contribute to the malignant phenotype of the cancer,inlcuding mutated cellular oncogenes or tumor suppressor genes.
D) The majority of anti-tumor T cell responses in cancer patents are specific for randomly mutated cellular proteins,which do not contribute to the malignant phenotype of the cancer.

E) Most T cell responses to tumors are specific for unmutated but over expressed tumor cell surface proteins.