Which Type of Molecules Are the Most Frequent Target of Allogeneic

Multiple Choice

Which type of molecules are the most frequent target of allogeneic immune responses against transplanted organs and why?

A) Endothelial adhesion molecules,because they are present in the blood vessels of grafted organs,where donor lymphocytes can interact with them
B) Human leukocyte antigens (HLA) ,because they are the most polymorphic proteins in the organs.
C) Lipids,because they easily cross through the membranes of lymphocytes
D) Polymorphic cytosolic proteins,because they are readily processed into peptides that can bind class I MHC molecules
E) Blood group antigens,because they are expressed on all red blood cells and endothelial cells