In Mice, an Allergic Response in the Airways Can Be

Multiple Choice

In mice, an allergic response in the airways can be induced by systemic immunization with a protein antigen (chicken ovalbumin) in an adjuvant that promotes Type II immune responses, followed by several exposures to aerosolized ovalbumin administered via the airways. Mice that have a genetic deficiency in expression of the receptor c-kit are resistant to this disease because:

A) They are unable to generate an IgE antibody response to ovalbumin.
B) They lack expression of the high affinity IgE receptor.
C) Their inflammatory cells do not respond to chemokine receptor stimulation.
D) They lack mast cells.
E) They lack B cells.