Unlike Defects in Antibodies or T Cell Functions, Defects in Complement

Multiple Choice

Unlike defects in antibodies or T cell functions, defects in complement components often lead to autoimmune-like symptoms, rather than to increased susceptibility to infections. This is because:

A) Complement components do not require antibodies to attack microbial pathogens.
B) The complement pathway normally functions to clear immune complexes from the circulation.
C) Complement inhibitory proteins are up-regulated by complement activation.
D) The complement pathway is part of the innate, rather than the adaptive immune response.
E) Partial activation of the complement cascade promotes phagocytosis of host cells.