Studies Have Shown That Secondary Lymphoid Tissues Are a Major

Multiple Choice

Studies have shown that secondary lymphoid tissues are a major reservoir of HIV in infected individuals. In part, this is due to the high numbers of viral target cells expressing CD4, such as T cells, macrophages, and dendritic cells. Surprisingly, secondary lymphoid tissues were also found to contain large numbers of infectious virus particles in the form of immune complexes. A comparison of the viral species found in these immune complexes indicates that they include virus particles that have been retained for over a year. The cells responsible for this reservoir of infectious HIV are:

A) HIV-specific B cells
B) Follicular dendritic cells
C) CD4 T cells
D) Subcapsular sinus macrophages
E) CD4⁺ dendritic cells