Effector Caspases Are Activated Downstream of Both Extrinsic and Intrinsic

Multiple Choice

Effector caspases are activated downstream of both extrinsic and intrinsic pathways of apoptosis. Consequently, cells lacking one or more of these enzymes show defects in apoptosis. An alternative means of eliminating the activity of an effector caspase would be to:

A) Generate a form of the pro-caspase with a mutation in the initiator caspase cleavage site
B) Express a mutant form the caspase that lacked the pro-domain
C) Express a constitutively active form of the initiator caspase
D) Generate a knockout mutation that prevented expression of the Fas receptor
E) Generate a mutation in the proteins required for autophagy