Experiments Performed with T-Cell Receptor Transgenic Mice Identified the Fate

Multiple Choice

Experiments performed with T-cell receptor transgenic mice identified the fate of developing thymocytes that failed positive selection. Based on these findings, examination of thymocytes in MHC class I-MHC class II-deficient mice (lacking all MHC class I and class II expression in the thymus) would show:

A) A 100-fold decrease in total thymocytes numbers
B) A block in T cell development at the CD4^-CD8^- double-negative stage
C) Normal numbers and subsets of thymocytes and peripheral T cells
D) Normal numbers of thymocytes, but no peripheral T cells
E) A block in T cell development at the CD4⁺CD8⁺ double-positive stage