Some CD1 Molecules Bind to Glycosphingolipids, and Are Recognized by a Subset

Multiple Choice

Some CD1 molecules bind to glycosphingolipids, and are recognized by a subset of T cells known as invariant NKT (iNKT) cells. The ability of these T cells to recognize different glycolipid constituents from microorganisms when they are bound to CD1d places these cells in the 'innate immune' category. While iNKT cells do express a fully rearranged $\alpha$ : $\beta$ T-cell receptor, one key feature of the T-cell receptors expressed on iNKT cells also places them in the 'innate immune' category. This feature is:

A) iNKT cells have a highly restricted T-cell receptor repertoire, with the majority of cells utilizing the same V $\alpha$ and J $\alpha$ rearrangement.
B) iNKT cells express receptors that are also expressed on NK cells.
C) iNKT cells express T-cell receptors that induce inhibitory, rather than activating signals.
D) iNKT cells do not generally express CD4 or CD8.
E) The T-cell receptors expressed on iNKT cells recognize both MHC class I and MHC class II molecules.