$\alpha$ $\beta$ TCRs Are Membrane-Bound Proteins Comprised of Two Polypeptides Linked by Polypeptides

Essay

$\alpha$ : $\beta$ TCRs are membrane-bound proteins comprised of two polypeptides linked by a disulfide bond. Both polypeptide components of the $\alpha$ : $\beta$ TCR are members of the immunoglobulin superfamily, and each of their domains share structural similarity with regions of antibody proteins. However, due to the different functions of TCRs versus antibodies, the overall domain organization of the TCR is not the same as for an antibody. In the cartoon in Figure Q14), describe three features that are incorrect illustrations of the $\alpha$ : $\beta$ TCR.