What Would Be the Expected Result of a Lysine Residue

Multiple Choice

What would be the expected result of a lysine residue being substituted with a serine residue in the BPG binding site of hemoglobin?

A) BPG would bind more tightly because of the loss of a positive charge.
B) BPG would bind more tightly because of the gain of a positive charge.
C) BPG would bind less tightly because of the loss of a positive charge.
D) BPG would bind less tightly because of the gain of a positive charge.
E) This substitution would have no effect on the binding of BPG.