SMAD4 Is a Tumor Suppressor Gene Located on Chromosome 18

Multiple Choice

SMAD4 is a tumor suppressor gene located on chromosome 18 that is known to be homozygously deleted in human lung cancer. If you were to perform comparative genomic hybridization using tissue from a lung cancer patient with a homozygous negative SMAD4 tumor, what ratio of green to red fluorescence would you expect?

A) A ratio of 1 on all of chromosome 18.
B) A ratio of 2 on the part of chromosome 18 containing the SMAD4 gene, with a value of 1 on the remainder of the chromosome.
C) A ratio of 0 on all of chromosome 18.
D) A ratio of 0 on the part of chromosome 18 containing the SMAD4 gene, with a value of 1 on the remainder of the chromosome.
E) A ratio of 1 on the part of chromosome 18 containing the SMAD4 gene, with a value of 0 on the remainder of the chromosome.