Which of the Following Sequence of Events Will Likely Lead

Multiple Choice

Which of the following sequence of events will likely lead to colorectal cancer?

A) Carcinoma develops, polyps form, cancer metastasizes.
B) Adenoma forms, polyps form, tumor-suppressor APC gene mutates, cancer metastasizes.
C) Tumor-suppressor APC gene mutates, polyps form, adenoma forms, carcinoma forms.
D) Proto-oncogenes mutate into tumor-suppressor genes, polyps form, cancer metastasizes.
E) Carcinoma becomes metastatic, polyps form, tumor-suppressor APC gene mutates.