Helen Has Type I Osteogenesis Imperfecta (OI), a Genetic Skeletal

Multiple Choice

Helen has type I osteogenesis imperfecta (OI) , a genetic skeletal disorder.Shown below is her DNA sequence for a portion of the coding region of the collagen type I gene, which contains the mutation responsible for her disorder.The corresponding wild-type sequence is shown also (only one DNA strand is shown in each case) . Helen 5'-AAACTCCACTTCTTCCAGTAC-3'
Normal 5'-AAACTCACTTCTTCCAGTAC-3'
What type of mutation does Helen carry?

A) Missense
B) Nonsense
C) Silent
D) Deletion
E) Frameshift