Burkitt's Lymphoma Is a Cancer of the Lymphatic System

Short Answer

Burkitt's lymphoma is a cancer of the lymphatic system. The endemic variant, common to equatorial Africa, commonly affects children who are also affected by chronic malaria. A recent study found that individuals with AA hemoglobin were twice as likely to develop Burkitt's lymphoma as those with the AS genotype. We saw a similar benefit of certain genotypes in cases
of sickle cell disease. Recall that individuals who are β^Aβ^S, β^Aβ^C, or β^Aβ^E have a survival and reproductive advantage over individuals who are homozygous β^Aβ^A (and therefore succumb more easily to malaria)and over those who are homozygous for the mutant alleles (and therefore suffer from hereditary anemia). Resistance to malaria and Burkitt's lymphoma are both an example of ________ advantage.