Sickle Cell Anemia Is Caused by a Single Mutation in the Hemoglobin

Multiple Choice

Sickle cell anemia is caused by a single mutation in the hemoglobin protein from a Glu to a Val, which results in which alteration in the hemoglobin subunits?

A) more neutral charges and formation of a nucleophilic contact point
B) fewer negative charges and formation of a hydrophobic contact point
C) fewer positive charges and formation of a hydrophobic contact point
D) more negative charges and formation of a hydrophilic contact point
E) more positive charges and formation of a hydrophilic contact point