Which Statement Does NOT Describe a Reason Why the Major

Multiple Choice

Which statement does NOT describe a reason why the major groove is more suited for sequence specificity interactions by DNA binding proteins?

A) The methyl group of T residues is found in the major groove.
B) The major groove is larger, allowing more space for protein side chains.
C) The minor groove is negatively charged because of the crowding by phosphates.
D) Hydrogen bond donor and acceptor patterns are different in the major groove for different base pairs.
E) Two hydrogen bond acceptors exist for all base pairs in the minor groove.