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Which Statement Is TRUE Regarding Topoisomerases During Synthesis of Nucleic

Question 90

Multiple Choice

Which statement is TRUE regarding topoisomerases during synthesis of nucleic acids by E. coli RNA polymerase?


A) DNA gyrase is required to relieve supercoils on the DNA exit side of the polymerase.
B) Since no strand cleavage occurs, supercoiling is not a factor in the action of RNA polymerase.
C) Positive supercoils are generated ahead of the transcription bubble.
D) Both the DNA and the RNA product will be supercoiled.
E) None of the statements is true.

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