Cyanide, Oligomycin, and 2,4-Dinitrophenol (DNP) Are Inhibitors of Mitochondrial Aerobic

Multiple Choice

Cyanide, oligomycin, and 2,4-dinitrophenol (DNP) are inhibitors of mitochondrial aerobic phosphorylation. Which statement CORRECTLY describes the mode of action of the three inhibitors?

A) Cyanide and 2,4-dinitrophenol inhibit the respiratory chain, and oligomycin inhibits the synthesis of ATP.
B) Cyanide inhibits the respiratory chain, whereas oligomycin and 2,4-dinitrophenol inhibit the synthesis of ATP.
C) Cyanide, oligomycin, and 2,4-dinitrophenol compete with O₂ for cytochrome oxidase (Complex IV) .
D) Oligomycin and cyanide inhibit synthesis of ATP; 2,4-dinitrophenol inhibits the respiratory chain.
E) Oligomycin inhibits the respiratory chain, whereas cyanide and 2,4-dinitrophenol prevent the synthesis of ATP.