Which Statement Is NOT True of the Reaction Catalyzed by the Pyruvate

Multiple Choice

Which statement is NOT true of the reaction catalyzed by the pyruvate dehydrogenase complex?

A) Biotin participates in the decarboxylation.
B) Both NAD⁺ and a flavin nucleotide act as electron carriers.
C) The reaction occurs in the mitochondrial matrix.
D) The substrate is held by the lipoyl-lysine "swinging arm."
E) Two different cofactors containing -SH groups participate.