Preparation of an Extract of Muscle Results in a Dramatic

Essay

Preparation of an extract of muscle results in a dramatic decrease in the concentration of citric acid cycle intermediates compared to their concentrations in the tissue. However, in 1935, Szent-Gyorgi showed that the production of CO₂ by the extract increased when succinate was added. In fact, for every mole of succinate added, many extra moles of CO₂ were produced. Explain this effect in terms of the known catabolic pathways.