Which Statement Is TRUE for "Far from Equilibrium" Reactions in a Cell

Multiple Choice

Which statement is TRUE for "far from equilibrium" reactions in a cell?

A) They are irreversible under all conditions.
B) Their standard free-energy changes are typically large and positive.
C) They are common control points of regulation in a metabolic pathway.
D) All of the statements are true.
E) None of the statements is true.