How Are the Opposing Pathways of Glycolysis and Gluconeogenesis Prevented

Multiple Choice

How are the opposing pathways of glycolysis and gluconeogenesis prevented from extensive futile cycling?

A) At least seven of the enzymes in the two pathways are different.
B) Key enzymes are regulated in a coordinated and reciprocal manner.
C) Catabolic and anabolic pathways do not take place in the same cellular compartments.
D) The overall free-energy change always favors the catabolic pathway.
E) Gluconeogenesis involves three endergonic bypass reactions.