Adam, Who Has a Cardiovascular Disease, Participated in a Research

Multiple Choice

Adam, who has a cardiovascular disease, participated in a research study to identify genetic variations linked to cardiovascular disease. His DNA, along with DNA from other patients suffering from the same cardiovascular disease, was obtained. For the purpose of comparison, the researchers also took DNA samples from participants who did not have the disease. Each participant's DNA was assessed to determine markers of genetic variation. The researchers found that genetic variations occurred more frequently in people who had the cardiovascular disease. This led them to pinpoint the region in the human genome linked to the disease. Which of the following approaches to gene identification and discovery did the researchers use in this study?

A) next-generation sequencing
B) linkage analysis
C) the Thousand Genomes Project
D) the genome-wide association method