Which of the Following Statements Describe(s) the Characteristics of an Enzyme

Multiple Choice

Which of the following statements describe(s) the characteristics of an enzyme active site that result in highly specific substrate selectivity and highly specific catalytic ability?

A) The active site is a highly specific three-dimensional cleft or pocket formed from different parts of the primary amino acid sequence.
B) The active site takes up only a small part of the total enzyme.
C) Amino acid side chains at the active site combine to create a microenvironment where the arrangement of atoms is uniquely matched to characteristics of only a single substrate species.
D) Mostly weak interactions-H-bonding, van der Waals interactions, and hydrophobic interactions-function to bind the substrate to the active site.
E) Some amino acids at the active site actively participate in making and breaking of bonds by lowering the activation energy of the overall reaction.